Thermo Fisher Scientific Anthrax Protective Antigen Polyclonal Antibody
Thermo Fisher Scientific의 Anthrax Protective Antigen Polyclonal Antibody는 Bacillus anthracis 보호 항원(PA)에 특이적인 토끼 유래 IgG 항체입니다. Western blot에 최적화되어 있으며 비결합형 액상 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 2–10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Bacteria |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues 186–192 of Anthrax PA |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not Determined |
| Storage Buffer | Whole serum/PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_1070415 |
Product Specific Information
- Suggested positive control: PA recombinant protein
Target Information
Anthrax infection is initiated by inhalation, ingestion, or cutaneous contact with Bacillus anthracis endospores. B. anthracis produces three polypeptides that comprise the anthrax toxin: protective antigen (PA), lethal factor (LF), and edema factor (EF).
PA binds to two related proteins on the cell surface, tumor epithelial marker 8 (TEM8)/anthrax toxin receptor (ATR) and capillary morphogenesis protein 2 (CMG2). Following PA binding to its receptor, it is cleaved into two fragments by a furin-like protease. The bound fragment binds both LF and EF; the resulting complex is endocytosed, enabling translocation of LF and EF into the cytoplasm. These toxins can cause rapid cell death and often the death of the organism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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