Thermo Fisher Scientific MLH1 Monoclonal Antibody (OTI5A7), TrueMAB
MLH1 단백질을 인식하는 단클론 항체로 Western blot에 적합. 인간, 마우스, 랫트 반응성. 동결건조 형태로 제공되며, 1 mg/mL 농도. DNA 불일치 복구 연구 및 MSI 관련 암 연구에 활용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI5A7 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 299–527 of human MLH1 produced in E. coli. |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
MLH1 is a DNA mismatch repair protein essential for maintaining genetic stability.
Defects in this pathway can cause microsatellite instability (MSI), associated with human carcinogenesis, including hereditary nonpolyposis colon cancer (HNPC).
MSH2 recognizes mismatched nucleotides during replication and recruits MLH1 and PMSH heterodimers to facilitate the repair process.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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