Thermo Fisher Scientific P2Y14 Polyclonal Antibody
Rabbit polyclonal antibody targeting human P2Y14 receptor. Validated for WB, IHC-P, and ICC/IF. High specificity with 100% human sequence identity. Supplied as liquid form at 1 mg/mL, stored at 4°C short term or -20°C long term. For research use only.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | – | View 2 publications |
| Immunohistochemistry (Paraffin) (IHC-P) | 4 µg/mL | – |
| Immunocytochemistry (ICC/IF) | 5–10 µg/mL | – |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 20 amino acid peptide from C-terminus of human P2RY14 / P2Y14 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2551440 |
Product Specific Information
Percent identity with other species by BLAST analysis:
- Human: 100%
- Monkey: 95%
Target Information
GPR105 (P2Y14 receptor) is expressed in brain, with ESTs isolated from kidney, placenta, uterus, and heart/melanocyte/uterus libraries.
G-protein Coupled Receptors (GPCRs) represent one of the largest families of signaling molecules, sharing a seven-transmembrane structural motif and existing in both active and inactive forms.
They are involved in signaling via G-proteins and downstream effectors, with regulatory mechanisms influencing physiological responses.
GPCRs are key drug targets, with examples including Zyprexa (Eli Lilly) and Claritin (Schering-Plough), both major pharmaceuticals in mental health and allergy treatment.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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