Thermo Fisher Scientific RanBP1 Polyclonal Antibody
RanBP1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB 및 IHC(P)에서 사용 가능. Human, Mouse, Rat 반응성. KLH 결합 합성 펩타이드 면역원 사용. Protein A 정제, 1 mg/mL 농도, -20°C 보관.
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Applications
Western Blot (WB)
- Assay-dependent
Immunohistochemistry (Paraffin) (IHC (P))
- Dilution: 1:400
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human RanBP1 (amino acids 86–116) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Ran/TC4-binding protein (RanBP1) interacts specifically with GTP-charged RAN.
RANBP1 encodes a 23-kDa protein that binds to RAN complexed with GTP but not GDP.
It does not activate the GTPase activity of RAN but enhances GTP hydrolysis by RanGAP1.
The RANBP1 cDNA encodes a 201-amino acid protein that shares 92% similarity with its mouse homolog.
In both mammalian cells and yeast, RanBP1 acts as a negative regulator of RCC1 by inhibiting RCC1-stimulated guanine nucleotide release from RAN.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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