Thermo Fisher Scientific ECD Polyclonal Antibody
ECD 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB 및 ICC/IF에 적합합니다. Human과 Mouse 시료에 반응하며, 고순도의 Affinity chromatography로 정제되었습니다. PBS/glycerol 용액 형태로 -20°C 보관이 권장됩니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human ECD (Accession O95905), corresponding to amino acid residues L389–V439 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2850003 |
Product Specific Information
Antibody detects endogenous levels of total ECD.
Target Information
Regulator of p53/TP53 stability and function. Inhibits MDM2-mediated degradation of p53/TP53 possibly by cooperating in part with TXNIP (PubMed:16849563, PubMed:23880345).
May be involved in transcriptional regulation. In vitro has intrinsic transactivation activity enhanced by EP300.
May be a transcriptional activator required for the expression of glycolytic genes (PubMed:19919181, PubMed:9928932).
Involved in regulation of cell cycle progression. Proposed to disrupt Rb–E2F binding leading to transcriptional activation of E2F proteins (PubMed:19640839).
The cell cycle–regulating function may depend on its RUVBL1-mediated association with the R2TP complex (PubMed:26711270).
May play a role in regulation of pre-mRNA splicing (PubMed:24722212).
[UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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