Thermo Fisher Scientific ATG13/KIAA0652 Polyclonal Antibody

Thermo Fisher Scientific ATG13/KIAA0652 Polyclonal Antibody

Applications and Tested Dilutions

• Western Blot (WB): 1:2,000–1:10,000
• Immunoprecipitation (IP): 2–10 µg/mg lysate

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt
• Based on 100% sequence identity, predicted to react with X. tropicalis, Bovine, Orangutan, and Chimpanzee

Target Information

Autophagy is a process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway, essential for normal growth control and nutrient preservation under starvation. This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein ATG1.
ATG13 forms a complex with ULK1, ULK2, and FIP200, which is a target of TOR phosphorylation under normal conditions. Inhibition of TOR by rapamycin or leucine deprivation leads to dephosphorylation of ATG13, ULK1, and ULK2, thereby inducing autophagy. Knockdown of ATG13 inhibits autophagosome formation.

Notice

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.