Thermo Fisher Scientific ATG13/KIAA0652 Polyclonal Antibody
ATG13/KIAA0652 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 Immunoprecipitation에 적합하며, 인간과 생쥐에 반응. 항원 친화 크로마토그래피로 정제된 액상 형태, 4°C 보관.
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Thermo Fisher Scientific ATG13/KIAA0652 Polyclonal Antibody
Applications and Tested Dilutions
- Western Blot (WB): 1:2,000–1:10,000
- Immunoprecipitation (IP): 2–10 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 450 to 500 of human Autophagy-related protein 13 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Phosphate/Tris citrate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, predicted to react with X. tropicalis, Bovine, Orangutan, and Chimpanzee
Target Information
Autophagy is a process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway, essential for normal growth control and nutrient preservation under starvation. This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein ATG1.
ATG13 forms a complex with ULK1, ULK2, and FIP200, which is a target of TOR phosphorylation under normal conditions. Inhibition of TOR by rapamycin or leucine deprivation leads to dephosphorylation of ATG13, ULK1, and ULK2, thereby inducing autophagy. Knockdown of ATG13 inhibits autophagosome formation.
Notice
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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