Thermo Fisher Scientific COMT Monoclonal Antibody (1G4-1A1)
COMT 단백질을 표적으로 하는 Mouse 단클론 항체로, Western blot과 ELISA에 적합합니다. 인체 반응성이 있으며, 고순도 친화성 크로마토그래피로 정제되었습니다. 연구용으로만 사용 가능하며, COMT 관련 신경전달물질 대사 연구에 유용합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1–5 µg/mL
ELISA
- Tested Dilution: 0.3 ng/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1G4-1A1 |
| Immunogen | COMT (AAH00419.2, 1 a.a. ~182 a.a) full-length recombinant protein with GST tag (MW of GST tag: 26 KDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
MNVGDKKGKI VDAVIQEHQP SVLLELGAYC GYSAVRMARL LSPGARLITI EINPDCAAIT QRMVDFAGMK DKVTLVVGAS QDIIPQLKKK YDVDTLDMVF LDHWKDRYLP DTLLLEECGL LRKGTVLLAD NVICPGAPDF LAHVRGSSCF ECTHYQSFLE YREVVDGLEK AIYKGPGSEA GP
Target Information
Catechol-O-methyltransferase (COMT) catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation is one of the major degradative pathways for catecholamine transmitters.
COMT also plays a role in the metabolism of catechol drugs used for treating hypertension, asthma, and Parkinson’s disease. It exists in two forms: soluble (S-COMT) and membrane-bound (MB-COMT), differing in their N-terminal regions. Multiple transcript variants arise from alternative translation initiation sites and promoters.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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