Thermo Fisher Scientific COMT Monoclonal Antibody (1G4-1A1)

Applications

Tested Dilution

Publications

Western Blot (WB)

1-5 µg/mL

-

ELISA (ELISA)

0.3 ng/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG2b, kappa

Class

Monoclonal

Type

Antibody

Clone

1G4-1A1

Immunogen

COMT (AAH00419.2, 1 a.a. approximately 182 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

See Label

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Sequence of this protein is as follows: MNVGDKKGKI VDAVIQEHQP SVLLELGAYC GYSAVRMARL LSPGARLITI EINPDCAAIT QRMVDFAGMK DKVTLVVGAS QDIIPQLKKK YDVDTLDMVF LDHWKDRYLP DTLLLEECGL LRKGTVLLAD NVICPGAPDF LAHVRGSSCF ECTHYQSFLE YREVVDGLEK AIYKGPGSEA GP

Target Information

Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.