Thermo Fisher Scientific TLK2 Monoclonal Antibody (OTI2D10), TrueMAB
TLK2 단백질을 인식하는 마우스 단클론 항체로, 파라핀 조직의 IHC(P) 실험에 적합합니다. 인간 시료 반응성이 있으며, 동결건조 형태로 제공됩니다. PBS 완충액에 8% trehalose 포함, -20°C 보관 권장. 연구용으로만 사용 가능합니다.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2D10 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1–296 of human TLK2 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
TLK2 (Tousled-like kinase 2) is a nuclear serine/threonine kinase involved in chromatin assembly regulation, intracellular signaling, protein phosphorylation, cell cycle control, chromatin modification, and DNA damage response.
TLK2 activity peaks during the S phase of the cell cycle and is regulated by phosphorylation. Inhibition of DNA replication rapidly decreases TLK2 activity, indicating its function is closely linked to DNA replication.
It is inactivated by phosphorylation at Ser-750, potentially by CHK1, and forms heterodimers with TLK1. TLK2 is widely expressed in fetal and adult tissues such as placenta, liver, kidney, pancreas, heart, and skeletal muscle.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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