Thermo Fisher Scientific NISCH Monoclonal Antibody (2C8)

Applications and Tested Dilution

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
LTGSTPMQVV TCLTRDSYLT HCFLQHLMVV LSSLERTPSP EPVDKDFYSE FGNKTTGKME NYELIHSSRV KFTYPSEEEI GDLTFTVAQK MAEPEKAPAL

Target Information

Acts either as the functional imidazoline-1 receptor (I1R) candidate or as a membrane-associated mediator of the I1R signaling. Binds numerous imidazoline ligands that induce initiation of cell-signaling cascades triggering cell survival, growth, and migration. Its activation by the agonist rilmenidine increases phosphorylation of MAPK1 and MAPK3 in RVLM neurons, leading to rilmenidine-evoked hypotension. Blocking activation with efaroxan abolishes rilmenidine-induced MAPK phosphorylation in RVLM neurons.
Acts as a modulator of Rac-regulated signal transduction pathways, suppressing Rac1-stimulated cell migration by interacting with PAK1 and inhibiting its kinase activity. Also interacts with RAC1 to inhibit Rac1-stimulated NF-kB response element and cyclin D1 promoter activation. Inhibits LIMK1 kinase activity by reducing LIMK1 Tyr-508 phosphorylation.
Inhibits Rac-induced cell migration and invasion in breast and colon epithelial cells, and lamellipodia formation when overexpressed. Plays a role in protection against apoptosis. Involved in association with IRS4 in enhancement of insulin activation of MAPK1 and MAPK3. Overexpression induces redistribution of cell surface ITGA5 integrin to intracellular endosomal structures.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.