Thermo Fisher Scientific ZHX2 Recombinant Rabbit Monoclonal Antibody (8N7O2)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

8N7O2

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 260-500 of human ZHX2. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:ZHX2,uniProtId:Q9Y6X8-1,ncbiNodeId:9606,antigenRange:260-500,antigenLength:837,antigenImageFileName:MA5-55598_ZHX2_Q9Y6X8-1_Rabbit.svg,antigenImageFileNamePDP:MA5-55598_ZHX2_Q9Y6X8-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.7 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 50% glycerol, 0.05% BSA

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Product Specific Information

Immunogen Sequence: VPLNTTKYNS ALDTNATMIN SFNKFPYPTQ AELSWLTAAS KHPEEHIRIW FATQRLKHGI SWSPEEVEEA RKKMFNGTIQ SVPPTITVLP AQLAPTKVTQ PILQTALPCQ ILGQTSLVLT QVTSGSTTVS CSPITLAVAG VTNHGQKRPL VTPQAAPEPK RPHIAQVPEP PPKVANPPLT PASDRKKTKE QIAHLKASFL QSQFPDDAEV YRLIEVTGLA RSEIKKWFSD HRYRCQRGIV H

Target Information

Zinc-fingers and homeobox (ZHX) proteins are transcription factors that interact with the activation domain of the A subunit of nuclear factor-Y (NF-YA). ZHX1-3 are ubiquitously expressed proteins expressed in various tissues. They act as transcriptional repressors and localize to the nucleus. The ZHX proteins contain two Cys(2)-His(2)-type zinc-finger motifs and five homeodomains (HDs). These domains allow the ZHX proteins to form homodimers, but they can also form heterodimers with each other. However, this dimerization is not required for repressor activity. Hypermethylation-mediated silencing of ZHX2 is an epigenetic event involved in hepatocellular carcinoma (HCC).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.