Thermo Fisher Scientific Nephrin Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Positive Control: Human kidney tissue, 293T, PANC-1, PC-12.

Target Information

Primary steroid-resistant nephrotic syndrome (SRNS) is characterized by childhood onset of proteinuria and progression to end-stage renal disease. Kidney podocytes and their slit diaphragms form the final barrier to urinary protein loss.
Congenital nephrotic syndrome (CNS) is caused by mutations in NPHS1 (nephrin) or NPHS2.
Nephrin, a recently identified protein, is a major component of the slit diaphragm, especially in podocyte foot processes. It functions as a cell adhesion molecule, crucial for maintaining the glomerular filtration barrier.
Mutations in the nephrin gene are linked to congenital nephrosis. Nephrin, along with Podocin and α-Actinin-4, plays a key role in podocyte structure and function. It is also implicated in anti-apoptotic activity and VEGF signaling pathways, contributing to glomerular integrity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.