Thermo Fisher Scientific DISC1 Polyclonal Antibody
DISC1 단백질을 인식하는 Thermo Fisher Scientific의 염소 유래 폴리클로날 항체로, 인간 시료에 반응합니다. Western blot 및 Peptide ELISA에 적합하며, 신경세포 발달 및 정신질환 연구에 활용됩니다. 액상 형태로 제공되며 -20°C에서 보관합니다.
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Thermo Fisher Scientific DISC1 Polyclonal Antibody
Applications
- Western Blot (WB)
Tested Dilution: 0.1–0.3 µg/mL
Publications: –
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide sequence (HSEDKRKTPLKVLE) corresponding to internal amino acids of DISC1 (aa 737–751) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_10979763 |
Product Specific Information
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:128,000.
Target Information
DISC1 (Disrupted in Schizophrenia 1) is a multifunctional protein interacting with various centrosomal and cytoskeletal proteins. It plays a crucial role in neuronal functions such as migration, neurite architecture, and intracellular transport. DISC1 is expressed in brain regions including the hippocampus, amygdala, cerebral cortex, cerebellum, and hypothalamus. Mutations or translocations involving DISC1 are associated with schizophrenia. The DISC1 protein contains both globular N-terminal and helical C-terminal domains, facilitating interactions with proteins like MIPT3, MAP1A, NUDEL, alpha-actinin 2, beta 4-spectrin, ATF-4, and ATF-5. Decreased DISC1 expression leads to abnormal neuronal development, implicating its role in dendritic growth and synapse formation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일: PA5-18555_DISC1_Q9NRI5-1_Goat.svg, PA5-18555_DISC1_Q9NRI5-1_Goat_PDP.jpeg)
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