Thermo Fisher Scientific Phospho-DYRK2/DYRK4 (Tyr382, Tyr264) Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human DYRK2/4 (Phospho-Tyr382/264). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:DYRK2/DYRK4,uniProtId:Q92630-1,ncbiNodeId:9606,antigenRange:382,antigenLength:601,antigenImageFileName:PA5-64575_DYRK2DYRK4_Q92630-1_Rabbit.svg,antigenImageFileNamePDP:PA5-64575_DYRK2DYRK4_Q92630-1_Rabbit_PDP.jpeg,sortOrder:1},{targetFamily:DYRK2/DYRK4,uniProtId:Q9NR20-1,ncbiNodeId:9606,antigenRange:264,antigenLength:520,antigenImageFileName:PA5-64575_DYRK2DYRK4_Q9NR20-1_Rabbit.svg,antigenImageFileNamePDP:PA5-64575_DYRK2DYRK4_Q9NR20-1_Rabbit_PDP.jpeg,sortOrder:2}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

RRID

AB_2664277

Product Specific Information

Phospho-DYRK2/DYRK4 (Tyr386, 268) Polyclonal Antibody detects endogenous levels of DYRK2/DYRK4 only when phosphorylated at Tyr386, 268.

Target Information

DYRK2 is a member of the dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family that is thought to be involved in cellular proliferation and apoptosis. Under normal conditions, nuclear but not cytoplasmic DYRK2 is ubiquitinated by MDM2, leading to its constitutive degradation. However, upon exposure to genotoxic stress, ATM phosphorylates DYRK2, leading to its dissociation from MDM2 and its phosphorylation of p53, thereby inducing apoptosis. Recent evidence also suggests that DYRK2 may serve as a scaffold that facilitates assembly of an E3 ubiquitin ligase.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.