Thermo Fisher Scientific INSIG1 Recombinant Rabbit Monoclonal Antibody (0Q2B5)
INSIG1 단백질을 인식하는 재조합 토끼 단클론 항체로, IHC(P) 및 ELISA에 적합합니다. HEK293 세포에서 발현되며 Protein A로 정제되었습니다. 콜레스테롤 항상성 연구에 유용하며, -20°C에서 보관합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 0Q2B5 |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 177–277 of human INSIG1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.19 mg/mL |
| Purification | Protein A |
| Storage buffer | PBS, pH 7.3, with 0.05% BSA, 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
Product Specific Information
Immunogen Sequence:
ASAKLDFANN VQLSLTLAAL SLGLWWTFDR SRSGLGLGIT IAFLATLITQ FLVYNGVYQY TSPDFLYIRS WLPCIFFSGG VTVGNIGRQL AMGVPEKPHS D
Target Information
Oxysterols regulate cholesterol homeostasis through liver X receptor (LXR) and sterol regulatory element-binding protein (SREBP) mediated signaling pathway.
This gene is an insulin-induced gene that encodes an endoplasmic reticulum (ER) membrane protein playing a critical role in regulating cholesterol concentrations in cells.
This protein binds to the sterol-sensing domains of SREBP cleavage-activating protein (SCAP) and HMG CoA reductase, and is essential for the sterol-mediated trafficking of the two proteins.
Alternatively spliced transcript variants encoding distinct isoforms have been observed.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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