Thermo Fisher Scientific DOCK3 Polyclonal Antibody
DOCK3 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. 인간 및 생쥐 시료에 반응하며 Western blot에 최적화. 액상 형태로 1 mg/mL 농도, PBS/glycerol buffer에 보존. 신경세포 신호전달 및 알츠하이머 관련 연구에 적합.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human DOCK3 (Accession Q8IZD9), corresponding to amino acid residues C550–S600 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2849995 |
Product Specific Information
Antibody detects endogenous levels of total DOCK3 (also known as MOCA).
Target Information
Dedicator of cytokinesis 3 (DOCK3), also named as MOCA and PBP, is a ~180 kDa protein involved in signal transduction. It functions as a guanine nucleotide exchange factor (GEF) activating small GTPases by exchanging GDP for GTP.
DOCK3 is associated with Alzheimer’s disease tangles and regulates amyloid precursor protein and beta-amyloid accumulation.
Overexpression of DOCK3 in neural cells promotes axonal outgrowth downstream of brain-derived neurotrophic factor (BDNF) signaling.
It binds and inactivates glycogen synthase kinase-3β (GSK-3β) at the plasma membrane, promoting axon branching and microtubule assembly.
By stimulating actin polymerization and microtubule assembly, DOCK3 plays a key role in BDNF-mediated signaling in the central nervous system.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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