Thermo Fisher Scientific Mimecan Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (IHC)

-

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human Mimecan. Recombinant protein control fragment (Product #RP-89834). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:OIF,uniProtId:P20774-1,ncbiNodeId:9606,antigenRange:167-287,antigenLength:298,antigenImageFileName:PA5-53019_OIF_P20774-1_Rabbit.svg,antigenImageFileNamePDP:PA5-53019_OIF_P20774-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2643974

Product Specific Information

Immunogen sequence: SLLEELSLAE NQLLKLPVLP PKLTLFNAKY NKIKSRGIKA NAFKKLNNLT FLYLDHNALE SVPLNLPESL RVIHLQFNNI ASITDDTFCK ANDTSYIRDR IEEIRLEGNP IVLGKHPNSF I

Highest antigen sequence identity to the following orthologs: Mouse - 87%, Rat - 88%.

Target Information

Mimecan induces ectopic bone formation in conjunction with transforming growth factor beta. Mimecan is a small proteoglycan which contains tandem leucine-rich repeats. Mimecan is encoded by the OGN gene, a member of the small leucine-rich proteoglycan (SLRP) family of proteins. Mimecan induces ectopic bone formation in conjunction with transforming growth factor beta (TGF-beta-1 or TGF-beta-2) and may regulate osteoblast differentiation. High expression of mimecan protein may be associated with elevated heart left ventricular mass. Alternative splicing results in multiple transcript variants of mimecan. Alternatively spliced transcript variants that encode mimecan have been found.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.