Thermo Fisher Scientific SPAG5 Polyclonal Antibody
인간 SPAG5 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF에 적합하며, 고순도 Affinity chromatography로 정제됨. 액상 형태, 1 mg/mL 농도, -20°C 보관.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:3,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human SPAG5 (Accession Q96R06), corresponding to amino acid residues E314–S364 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2853495 |
Product Specific Information
Antibody detects endogenous levels of total SPAG5.
Target Information
SPAG5 (sperm associated antigen 5), also known as MAP126, hMAP126, DEEPEST or Astrin, is a 1,193 amino acid protein expressed at high levels in testis and at lower levels in liver, placenta, pancreas, colon, and thymus.
It localizes to spindle poles during prophase and throughout the spindle during metaphase and anaphase. SPAG5 is essential for proper spindle formation and is involved in the dynamic and functional regulation of mitotic spindles.
Additionally, SPAG5 contributes to sister chromatid cohesion and separation and regulates chromosome integrity through its association with chromatids.
SPAG5 forms a homodimer with a long stalk and globular head domain characterized by aster-like structures. Upon DNA damage, SPAG5 may be phosphorylated by ATR or ATM.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일: PA5-104167_SPAG5_Q96R06-1_Rabbit.svg, PA5-104167_SPAG5_Q96R06-1_Rabbit_PDP.jpeg)
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