Thermo Fisher Scientific DNAJB2 Monoclonal Antibody (OTI4D12)
DNAJB2 단백질을 인식하는 Thermo Fisher Scientific의 Mouse Monoclonal Antibody (OTI4D12). Western blot, ICC/IF, Flow cytometry에 사용 가능. 고순도 친화 크로마토그래피 정제, 인간 반응성, 뇌 특이적 단백질 연구에 적합.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4D12 |
| Immunogen | Full length human recombinant protein of DNAJB2 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.53 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2724215 |
Target Information
The DnaJ family is one of the largest of all the chaperone families and has evolved with diverse cellular localization and functions. The presence of the J domain defines a protein as a member of the DnaJ family. DnaJ heat shock induced proteins originate from Escherichia coli and are regulated by the htpR protein. These proteins are critical components of the HSP70 chaperone machine, interacting with HSP70 to stimulate ATP hydrolysis. They contain cysteine-rich regions forming zinc fingers that create a peptide-binding domain responsible for chaperone activity.
DnaJ proteins mediate proteolysis and regulate protein degradation, exocytosis, and endocytosis. DnaJB2 (DnaJ homolog subfamily B member 2), also known as HSJ1 or HSPF3, is expressed predominantly in the brain, especially in the frontal cortex and hippocampus. Two isoforms are produced via alternative splicing.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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