Thermo Fisher Scientific Human TDP-43 Synthetic Peptide
인간 TDP-43 중심부 18개 아미노산 서열 기반 합성 펩타이드로, 항체 PA5-20409의 블로킹 펩타이드로 사용 가능. HIV-1 TAR DNA 결합 및 CFTR 스플라이싱 조절 연구에 적합. 고순도 정제된 액상 형태, 연구용 전용 시약.
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Thermo Fisher Scientific Human TDP-43 Synthetic Peptide
Applications
- Control (Ctrl): Assay-dependent
- Blocking Assay (BLOCK): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 18 amino acids near the center of human TDP43.
PEP-0526 can be used as a blocking peptide with polyclonal antibody PA5-20409.
Target Information
TDP43 was first identified as a novel cellular protein that binds to HIV-1 virus TAR DNA sequence motifs and acts as a transcriptional repressor to the HIV-1 LTR.
It also regulates the splicing of exon 9 of the cystic fibrosis transmembrane conductance regulator (CFTR), likely through association with UG repeats at the 3′ splice site.
A hyperphosphorylated, ubiquitinated, and cleaved form of TDP43, known as pathologic TDP43, is the major disease protein in ubiquitin-positive, tau-, and alpha-synuclein-negative frontotemporal dementia (FLTD-U).
TDP43 is not related to TRBP1, an RNA-binding protein that binds HIV-1 TAR RNA sequences.
Usage Note
For Research Use Only. Not for use in diagnostic procedures.
Not for resale without express authorization.
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