Thermo Fisher Scientific ACAT2 Monoclonal Antibody (4A5)

Applications and Tested Dilution

Product Specifications

Product Specific Information

Protein sequence:

MNAGSDPVVI VSAARTIIGS FNGALAAVPV QDLGSTVIKE VLKRATVAPE DVSEVIFGHV LAAGCGQNPV RQASVGAGIP YSVPAWSCQM ICGSGLKAVC LAVQSIGIGD SSIVVAGGME NMSKAPHLAY LRTGVKIGEM PLTDSILCDG LTDAFHNCHM GITAENVAKK WQVSREDQDK VAVLSQNRTE NAQKAGHFDK EIVPVLVSTR RGLIEVKTDE FPRHGSNIEA MSKLKPYFLT DGTGTVTPAN ASGINDGAAA VVLMKKSEAD KRGLTPLARI VSWSQVGVEP SIMGIGPIPA IKQAVTKAGW SLEDVDIFEI NEAFAAVSAA IVKELGLNPE KVNIEGGAIA LGHPLGASGC RILVTLLHTL ERMGRSRGVA ALCIGGGMGI AMCVQRE

Target Information

This gene represents a member of the frizzled gene family, which encodes 7-transmembrane domain proteins acting as receptors for Wnt signaling proteins. The encoded protein contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains. Unlike other family members, it lacks a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/β-catenin signaling cascade, thereby inhibiting oncogenic transformation, cell proliferation, and suppression of apoptosis. Alternative splicing results in multiple transcript variants.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.