Thermo Fisher Scientific SIPA1L3 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:500

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human SIPA1L3. Recombinant protein control fragment (Product #RP-98995). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:SIPA1L3,uniProtId:O60292-1,ncbiNodeId:9606,antigenRange:1303-1384,antigenLength:1781,antigenImageFileName:PA5-59853_SIPA1L3_O60292-1_Rabbit.svg,antigenImageFileNamePDP:PA5-59853_SIPA1L3_O60292-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.4 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2647313

Product Specific Information

Immunogen sequence: KGGSSDSGID TTLYTSSPSC MSLAKAPRPA KPHKPPGSMG LCGGGREAAG RSHHADRRRE VSPAPAVAGQ SKGYRPKLYS SG

Highest antigen sequence identity to the following orthologs: Mouse - 89%, Rat - 89%.

Target Information

Signal-induced proliferation associated-like protein 2 (SIPA1L3) is a member of the SIPA1 family of RapGAPs. SIPA1L3 was cloned as a novel molecular component of tight junctions and adherens junctions, suggesting that may function to balance Rap1 by counteracting RapGEFs. Recent studies of SIPA indicate that its deregulation can cause myeloproliferative stem cell disorders in mice and increased metastases in human cancers. Other studies suggest SIPA1L1 may play important roles in embryo development and control of cell proliferation. Based on the amount of homology between SIPA family members, it is possible that SIPA1L3 plays other roles development and cell proliferation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.