Thermo Fisher Scientific Dectin 2 Polyclonal Antibody
Dectin-2 단백질을 인식하는 Rabbit Polyclonal Antibody로 인간 시료에 반응합니다. Western blot, IHC, ICC/IF에 적합하며 CLEC6A 유래 합성 펩타이드로 면역화되었습니다. 액상 형태, 1 mg/mL 농도, 친화 크로마토그래피로 정제되었습니다.
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- PA599873
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- pk
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CLEC6A (Accession Q6EIG7), corresponding to amino acid residues Y60–M110 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2818806 |
Product Specific Information
Antibody detects endogenous levels of total CLEC6A.
Target Information
Dectin-2 is a C-type lectin expressed by dendritic cells, macrophages, and inflammatory monocytes. It is a type II membrane receptor with a short cytoplasmic tail and a C-terminal C-type lectin domain. Dectin-2 recognizes high mannose structures and mediates cytokine production from dendritic cells and other antigen-presenting cells.
Although Dectin-2 lacks obvious signaling motifs, it employs FcRg for internalization and activation of the NF-kappaB pathway, leading to cytokine production. Despite only 20–25% homology with Dectin-1, Dectin-2 functions similarly as a pattern recognition receptor (PRR) for fungal infections, activating both innate (Syk–CARD9 pathway) and adaptive immune responses through dendritic cell activation.
Thus, Dectin-2 serves as a connector molecule between innate and adaptive immunity at the dendritic cell level.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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