Thermo Fisher Scientific TP53INP2 Polyclonal Antibody
Human 및 Mouse 시료에 반응하는 TP53INP2 단백질에 대한 Rabbit Polyclonal 항체. IHC(P)와 ICC/IF에 사용 가능하며, 항원 친화 크로마토그래피로 정제됨. PBS와 글리세롤 버퍼에 보관되며, 연구용으로 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A genomic peptide made to a C-terminal region of the human TP53INP2 protein (within residues 100–220). [Swiss-Prot Q8IXH6] |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.6 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 30% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2718815 |
Target Information
TP53INP2 (tumor protein p53 inducible nuclear protein 2), also known as DOR or PINH, is a 220 amino acid nuclear protein expressed in developing murine brain and spinal cord, as well as in the sensory and motor neuron tracts of the peripheral nervous system.
It is a novel protein involved in autophagy of mammalian cells. TP53INP2 translocates from the nucleus to autophagosome structures after activation of autophagy by rapamycin or starvation.
Necessary for autophagosome development and considered a scaffold protein, TP53INP2 recruits LC3 and/or LC3-related proteins (such as GABARAP and GABARAP-like2) to the autophagosome membrane by interacting with the transmembrane protein TMEM49.
The gene encoding TP53INP2 is located on human chromosome 20, which contains approximately 63 million bases and encodes over 600 genes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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