Thermo Fisher Scientific TP53INP2 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Target Information

TP53INP2 (tumor protein p53 inducible nuclear protein 2), also known as DOR or PINH, is a 220 amino acid nuclear protein expressed in developing murine brain and spinal cord, as well as in the sensory and motor neuron tracts of the peripheral nervous system.
It is a novel protein involved in autophagy of mammalian cells. TP53INP2 translocates from the nucleus to autophagosome structures after activation of autophagy by rapamycin or starvation.
Necessary for autophagosome development and considered a scaffold protein, TP53INP2 recruits LC3 and/or LC3-related proteins (such as GABARAP and GABARAP-like2) to the autophagosome membrane by interacting with the transmembrane protein TMEM49.
The gene encoding TP53INP2 is located on human chromosome 20, which contains approximately 63 million bases and encodes over 600 genes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.