Thermo Fisher Scientific MTM1 Monoclonal Antibody (1C10)
MTM1 단백질을 표적으로 하는 Mouse IgG2a 단클론 항체로, Western blot, IHC, ELISA에 사용 가능. 인간 MTM1에 특이적으로 반응하며 연구용으로 적합. PBS buffer에 보관, -20°C에서 안정적이며 방부제 미포함.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 3 µg/mL |
| ELISA | 1 ng/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1C10 |
| Immunogen | MTM1 (AAH30779, 1–100 a.a.) partial recombinant protein with GST tag (MW of GST tag: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
MASASTSKYN SHSLENESIK RTSRDGVNRD LTEAVPRLPG ETLITDKEVI YICPFNGPIK GRVYITNYRL YLRSLETDSS LILDVPLGVI SRIEKMGGAT
Target Information
Human MTM1 is a 603 amino-acid protein mutated in myotubular myopathy. The related protein hMTMR2 is associated with Charcot-Marie-Tooth neuropathy. Myotubularin acts as a lipid phosphatase on phosphatidylinositol 3-monophosphate, regulating the PI 3-kinase pathway and membrane trafficking. Wildtype myotubularin can dephosphorylate PI 3-P and PI 4-P in vitro, reducing PI 3-P levels by down-regulating PI 3-K activity and promoting PI 3-P degradation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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