Thermo Fisher Scientific Phospho-PLK1 (Thr210) Recombinant Rabbit Monoclonal Antibody (PLK1T210-C2), APC
인간 PLK1(Thr210) 인산화형을 인식하는 재조합 토끼 단클론 항체. APC 형광 표지로 유세포분석(Flow Cytometry)에 적합. 고특이적 단백질 인식 및 세포 증식 관련 연구용. 4°C 보관, Protein A/G 정제.
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Applications
Flow Cytometry (Flow)
- Tested Dilution: 5 µL / 1×10⁶ cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | PLK1T210-C2 |
| Immunogen | A synthetic phospho-peptide corresponding to residues surrounding Thr210 of human phospho PLK1. |
| Conjugate | APC |
| Excitation/Emission Max | 651 / 660 nm |
| Form | Liquid |
| Purification | Protein A/G |
| Storage Buffer | PBS with 0.20% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2897061 |
Additional Formats
- Unconjugated (MA5-37124)
- FITC (MA5-37126)
- PE (MA5-37125)
- Custom conjugation available upon request
Target Information
PLK1 is a serine/threonine kinase involved in cell mitosis and serves as a marker of cell proliferation. It plays a critical role in carcinogenesis. Polo-like kinase proteins function by binding and phosphorylating proteins already phosphorylated on specific motifs recognized by POLO box domains. PLK1 phosphorylates multiple substrates including BORA, BUB1B/BUBR1, CCNB1, CDC25C, CEP55, ECT2, ERCC6L, FBXO5/EMI1, FOXM1, KIF20A/MKLP2, CENPU, NEDD1, NINL, NPM1, NUDC, PKMYT1/MYT1, KIZ, PPP1R12A/MYPT1, PRC1, RACGAP1/CYK4, SGOL1, STAG2/SA2, TEX14, TOPORS, TP73, TPT1, and WEE1. It is essential for centrosome function and bipolar spindle assembly.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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