Thermo Fisher Scientific PON3 Monoclonal Antibody (454929)
PON3 단백질을 인식하는 Rat IgG2a 단일클론 항체로, Human, Mouse, Rat 시료에서 Western blot 검출에 적합합니다. PON1 및 PON2와 교차반응하지 않으며, 단백질 A/G로 정제된 무보존제 제품입니다. 연구용으로만 사용 가능합니다.
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Applications
- Western Blot (WB): Tested at 0.5 µg/mL
- Publications: [References not provided]
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rat / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 454929 |
| Immunogen | E. coli-derived recombinant human PON3 (Ala30–Leu354) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.5 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 5% trehalose |
| Contains | No Preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2607774 |
Product Specific Information
This antibody detects endogenous human, mouse, and rat PON3 in Western blots.
It does not cross-react with recombinant human PON1 or PON2.
Reconstitute at 0.5 mg/mL in sterile PBS before use.
Target Information
Paraoxonase-1 (PON1) is a calcium-dependent ester hydrolase associated with apoA-I in HDL and prevents LDL oxidation.
Polymorphisms in the human PON1 gene are linked to coronary artery disease.
PON2 is an intracellular protein protecting cells against oxidative damage.
PON3 shares similar activity with PON1 but differs in substrate specificity.
Both PON1 and PON3 are implicated in reducing the risk of coronary artery disease and atherosclerosis.
Human PON3 protein contains three conserved cysteine residues found in PON1, essential for in vivo activity.
PON1-based catalytic scavengers may provide protection against organophosphate intoxication.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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