Thermo Fisher Scientific CTCF Polyclonal Antibody

Thermo Fisher Scientific CTCF Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.

Target Information

Transcriptional factor CTCF is a ubiquitously expressed 11-zinc finger domain-containing, DNA-binding nuclear phosphoprotein involved in multiple aspects of normal gene regulation, including transcriptional repression and activation, gene silencing, chromatin insulation, and regulation of imprinted sites.
CTCF interacts with the CCCTC motif on DNA using different combinations of zinc finger domains and can bind to HAT- and HDAC-containing complexes, influencing transcriptional activation or repression.
It plays roles in transactivation of the APPB gene, silencing of the c-myc gene, insulation of human beta-globin and DMI myotonic dystrophy loci, and imprinting control of IGF2 and H19 regions.
Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors.

Usage Note

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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