Thermo Fisher Scientific CTCF Polyclonal Antibody
CTCF 단백질을 인식하는 Thermo Fisher Scientific의 rabbit polyclonal 항체. WB, IHC, ICC/IF 등에 사용 가능. 고순도 항원 친화 크로마토그래피 정제, Lyophilized 형태로 제공. 인간, 마우스, 랫트 반응성. 연구용으로만 사용.
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Thermo Fisher Scientific CTCF Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–0.5 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 0.5–1 µg/mL |
| Immunocytochemistry (ICC/IF) | 5 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | E.coli-derived human CTCF recombinant protein (Position: K521–R727) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 500 µg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 5 mg BSA |
| Contains | 0.05 mg sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2746203 |
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Target Information
Transcriptional factor CTCF is a ubiquitously expressed 11-zinc finger domain-containing, DNA-binding nuclear phosphoprotein involved in multiple aspects of normal gene regulation, including transcriptional repression and activation, gene silencing, chromatin insulation, and regulation of imprinted sites.
CTCF interacts with the CCCTC motif on DNA using different combinations of zinc finger domains and can bind to HAT- and HDAC-containing complexes, influencing transcriptional activation or repression.
It plays roles in transactivation of the APPB gene, silencing of the c-myc gene, insulation of human beta-globin and DMI myotonic dystrophy loci, and imprinting control of IGF2 and H19 regions.
Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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