Thermo Fisher Scientific CaV1.2 Polyclonal Antibody
CaV1.2 단백질을 인식하는 Thermo Fisher Scientific의 다클론 항체로, WB, IHC, ICC 등 다양한 응용 가능. 기니피그 유래 IgG 형식, 비결합 상태로 제공. 동결건조 형태로 -20°C 보관. 연구용으로만 사용 가능.
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Applications
| Application | Tested Dilution | Notes |
|---|---|---|
| Western Blot (WB) | 1:200 | |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent | |
| Immunocytochemistry (ICC/IF) | Assay-dependent |
Product Specifications
| Property | Description |
|---|---|
| Host / Isotype | Guinea pig / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide corresponding to amino acid residues 848–865 of rat CaV1.2 (intracellular loop between domains II and III) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.8 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2857200 |
Product Specific Information
- Reconstitute antibody with 50 µL of double distilled water (DDW).
- Store the reconstituted solution at 4°C for up to 1 week.
- For longer storage, aliquot and keep at -20°C.
- Avoid multiple freeze-thaw cycles.
- Centrifuge all antibody preparations before use (10,000 × g, 5 min).
Peptide sequence: (C)TTKINMD DLQPSENEDK S
Homology:
- Mouse: identical amino acid residues
- Guinea pig: 17/18 identical
- Human, rabbit: 16/18 identical
Target Information
CACNA1C encodes the alpha-1 subunit of a voltage-dependent calcium channel, which mediates calcium ion influx upon membrane polarization. The alpha-1 subunit contains 24 transmembrane segments forming the ion-conducting pore. The calcium channel is composed of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio.
Multiple isoforms exist due to gene variation or alternative splicing. The CACNA1C protein binds to and is inhibited by dihydropyridine.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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