Thermo Fisher Scientific FGR Monoclonal Antibody (1B12)
FGR 단백질을 인식하는 Mouse IgG2a 단일클론 항체(1B12)로, WB, IHC, ELISA에 적합합니다. 인간, 마우스, 랫트 반응성이 있으며, PBS buffer에 보존된 액상 형태입니다. 연구용으로만 사용 가능합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 3 µg/mL |
| ELISA | 0.3 ng/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1B12 |
| Immunogen | FGR (AAH64382, 1–90 a.a.) partial recombinant protein with GST tag (MW of GST tag alone: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
MGCVFCKKLE PVATAKEDAG LEGDFRSYGA ADHYGPDPTK ARPASSFAHI PNYSNFSSQA INPGFLDSGT IRGVSGIGVT LFIALYDYEA
Target Information
FGR is a SRC-related kinase present in hematopoietic cells. It signals within multiple pathways, including the integrin pathway and downstream of chemokine and cytokine receptors. This protein contains N-terminal sites for myristylation and palmitoylation, a PTK domain, and SH2 and SH3 domains, which mediate protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively.
It localizes to plasma membrane ruffles and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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