Thermo Fisher Scientific CHEK2 Monoclonal Antibody (6B8)
CHEK2 단백질을 인식하는 Mouse Monoclonal Antibody (Clone 6B8). Western blot 및 ELISA에 적합하며 인간 시료에 반응. Affinity chromatography로 정제된 액상 형태, -20°C 보관. DNA 손상 반응 및 종양 억제 연구용.
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Thermo Fisher Scientific CHEK2 Monoclonal Antibody (6B8)
Applications and Tested Dilution
- Western Blot (WB): 1–5 µg/mL
- ELISA: 10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 6B8 |
| Immunogen | CHEK2 (AAH04207, 1–100 a.a) partial recombinant protein with GST tag (GST tag MW: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
MSRESDVEAQ QSHGSSACSQ PHGSVTQSQG SSSQSQGISS SSTSTMPNSS QSSHSSSGTL SSLETVSTQE LYSIPEDQEP EDQEPEEPTP APWARLWALQ
Target Information
CHEK2 (CHK2) is a serine/threonine kinase involved in the DNA damage checkpoint pathway. Mutations in CHK2 are associated with various cancers. It phosphorylates tumor suppressor proteins and is activated by DNA damage. CHK2 also phosphorylates BRCA1, aiding in cell survival after DNA damage. Mutations in CHK2 are linked to Li-Fraumeni syndrome, sarcomas, breast cancer, and brain tumors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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