Thermo Fisher Scientific CD63/MLA1 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Target Information

CD63 (LAMP-3, lysosome-associated membrane protein-3) is a glycoprotein of the tetraspanin family found in late endosomes, lysosomes, and secretory vesicles of various cell types. It is also present on the plasma membrane following cell activation and serves as a basophil activation marker. In mast cells, CD63 exposure does not require activation. CD63 interacts with integrins, influences phagocytosis and cell migration, and is involved in H/K-ATPase trafficking and ROMK1 channel regulation. It functions as a T-cell costimulation molecule and is used to predict prognosis in early-stage carcinomas. CD63 is expressed on activated platelets and translocated to the plasma membrane upon activation. It is also found in monocytes, macrophages, and weakly expressed on granulocytes, B, and T cells. CD63 is identical to melanoma-associated antigen ME491 and platelet antigen PTLGP40. Dysfunction of CD63 is associated with melanoma and Hermansky-Pudlak Syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.