Thermo Fisher Scientific KIR2DL5B Polyclonal Antibody
Rabbit polyclonal antibody targeting human KIR2DL5B for ICC/IF applications. Unconjugated form with 1 mg/mL concentration. Suitable for research use in studying NK cell receptor signaling and immune regulation. Stored at -20°C and shipped on wet ice.
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Thermo Fisher Scientific KIR2DL5B Polyclonal Antibody
Applications
- Immunocytochemistry (ICC/IF)
Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide derived from the internal region of human KIR2DL5B |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2555812 |
Target Information
KIR2DL5A and KIR2DL5B are Killer cell immunoglobulin-like receptors (KIRs), transmembrane glycoproteins expressed by natural killer (NK) cells and subsets of T cells.
The KIR genes are polymorphic and highly homologous, located on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC).
KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain.
- Long cytoplasmic domains transduce inhibitory signals via ITIM motifs.
- Short cytoplasmic domains lack ITIM motifs and instead associate with TYRO protein tyrosine kinase binding protein to transduce activating signals.
KIR proteins play a crucial role in immune response regulation. Functionally, KIR2DL5A and KIR2DL5B are receptors on NK cells for HLA-C alleles and prevent cell lysis by inhibiting NK cell activity.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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