Thermo Fisher Scientific KIR2DL5B Polyclonal Antibody

Thermo Fisher Scientific KIR2DL5B Polyclonal Antibody

Applications

• Immunocytochemistry (ICC/IF)
  Tested Dilution: 1:100–1:500

Product Specifications

Target Information

KIR2DL5A and KIR2DL5B are Killer cell immunoglobulin-like receptors (KIRs), transmembrane glycoproteins expressed by natural killer (NK) cells and subsets of T cells.
The KIR genes are polymorphic and highly homologous, located on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC).
KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain.

• Long cytoplasmic domains transduce inhibitory signals via ITIM motifs.
• Short cytoplasmic domains lack ITIM motifs and instead associate with TYRO protein tyrosine kinase binding protein to transduce activating signals.

KIR proteins play a crucial role in immune response regulation. Functionally, KIR2DL5A and KIR2DL5B are receptors on NK cells for HLA-C alleles and prevent cell lysis by inhibiting NK cell activity.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.