Thermo Fisher Scientific TNFRSF8 Monoclonal Antibody (3B9)
인간 CD30(TNFRSF8)을 표적으로 하는 Mouse IgG1 단클론 항체. ELISA 검증 완료, Affinity chromatography로 정제된 액상 형태. PBS(pH 7.4)에 보존제로 없이 -20°C 보관. Hodgkin 림프종 및 CD30+ 세포 연구용.
- 카탈로그번호
- H00000943-M01
- 판매단위
- pk
카탈로그
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Applications
- ELISA (ELISA)
Tested Dilution: 0.03 ng/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3B9 |
| Immunogen | TNFRSF8 (NP_001234, 21–133 a.a) partial recombinant protein with GST tag (MW of GST tag: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
QDRPFEDTCH GNPSHYYDKA VRRCCYRCPM GLFPTQQCPQ RPTDCRKQCE PDYYLDEADR CTACVTCSRD DLVEKTPCAW NSSRVCECRP GMFCSTSAVN SCARCFFHSV CPA
Target Information
CD30 (Ki-1, TNF Receptor Superfamily Member 8) is a type I transmembrane glycoprotein belonging to the TNF receptor superfamily.
Originally identified as a cell surface antigen on Hodgkin and Reed-Sternberg cells using monoclonal antibody Ki-1, CD30 interacts with its ligand CD30L (CD153) to mediate diverse biological effects including cell proliferation, activation, differentiation, and apoptosis.
CD30 plays a critical role in Hodgkin’s disease and other CD30+ lymphomas. It acts as a costimulatory molecule in thymic negative selection and is expressed on Hodgkin’s and Reed-Sternberg cells, some non-Hodgkin’s lymphomas, virus-infected T and B cells, and activated normal T/B cells.
In T cells, CD30 expression is associated with Th2-type cytokine-producing subsets and CD4+/CD8+ thymocytes co-expressing CD45RO and IL4 receptor. Soluble CD30 (sCD30) serves as a marker of Th2 immune response. TRAF2 and TRAF5 interact with CD30, activating NF-kappaB signaling.
CD30 is a positive regulator of apoptosis, limiting autoreactive CD8 effector T cell proliferation and protecting against autoimmunity. Two alternatively spliced transcript variants encoding distinct isoforms have been reported.
CD30 is expressed by mononuclear cells in Hodgkin’s lymphoma, Reed-Sternberg cells, and most Anaplastic Large Cell Lymphomas (ALCL), as well as embryonal carcinomas.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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