Thermo Fisher Scientific CD276 Monoclonal Antibody (3E4)

Applications

Western Blot (WB)

• Tested Dilution: 1–5 µg/mL

ELISA

• Tested Dilution: 10 µg/mL

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
ITPQRSPTGA VEVQVPEDPV VALVGTDATL RCSFSPEPGF SLAQLNLIWQ LTDTKQLVHS FTEGRDQGSA YANRTALFPD LLAQGNASLR LQRVRVADEG SFTCFVSIRD FGSAAVSLQV AAPYSKPSMT LEPNKDLRPG DTVTITCSSY RGYPEAEVFW QDGQGVPLTG NVTTSQMANE QGLFDVHSVL RVVLGANGTY SCLVRNPVLQ QDAHGSVTIT GQPMT

Target Information

CD276 is a member of the B7 family of co-stimulatory molecules, also known as B7-H3.
It is a type I transmembrane protein that:

• Induces proliferation of CD4+ and CD8+ T cells
• Enhances generation of cytotoxic T cells
• Stimulates production of interferon gamma

Expression can be induced on dendritic cells and monocytes by inflammatory cytokines.
CD276 is widely expressed in peripheral tissues including heart, kidney, testis, and colon.
In humans, CD276 exists as two isoforms resulting from gene duplication and differential splicing.
It has therapeutic potential for regulating cell-mediated immune responses to cancer, particularly in combination with anti-angiogenic therapy.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.