Thermo Fisher Scientific CD276 Monoclonal Antibody (3E4)
인체 반응성 CD276(B7-H3) 단클론 항체로, Western Blot 및 ELISA에 사용 가능. 마우스 IgG1, kappa 동종형이며 비결합 상태로 제공. 친화 크로마토그래피로 정제되어 PBS(pH 7.4)에 보존. 암 연구 및 면역반응 조절 관련 연구용에 적합.
- 카탈로그번호
- H00080381-M30
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1–5 µg/mL
ELISA
- Tested Dilution: 10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3E4 |
| Immunogen | CD276 (AAH62581.1, 237–461 a.a.) partial recombinant protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
ITPQRSPTGA VEVQVPEDPV VALVGTDATL RCSFSPEPGF SLAQLNLIWQ LTDTKQLVHS FTEGRDQGSA YANRTALFPD LLAQGNASLR LQRVRVADEG SFTCFVSIRD FGSAAVSLQV AAPYSKPSMT LEPNKDLRPG DTVTITCSSY RGYPEAEVFW QDGQGVPLTG NVTTSQMANE QGLFDVHSVL RVVLGANGTY SCLVRNPVLQ QDAHGSVTIT GQPMT
Target Information
CD276 is a member of the B7 family of co-stimulatory molecules, also known as B7-H3.
It is a type I transmembrane protein that:
- Induces proliferation of CD4+ and CD8+ T cells
- Enhances generation of cytotoxic T cells
- Stimulates production of interferon gamma
Expression can be induced on dendritic cells and monocytes by inflammatory cytokines.
CD276 is widely expressed in peripheral tissues including heart, kidney, testis, and colon.
In humans, CD276 exists as two isoforms resulting from gene duplication and differential splicing.
It has therapeutic potential for regulating cell-mediated immune responses to cancer, particularly in combination with anti-angiogenic therapy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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