Thermo Fisher Scientific BCR Polyclonal Antibody
Human BCR 단백질을 인식하는 Rabbit Polyclonal Antibody로, IHC 및 ICC/IF 실험에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol buffer에 보존. 연구용으로만 사용.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human BCR. Recombinant protein control fragment (Product #RP-96534) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2790569 |
Product Specific Information
Immunogen sequence:
VDPVGFAEAW KAQFPDSEPP RMELRSVGDI EQELERCKAS IRRLEQEVNQ ERFRMIYLQT LLAKEKKSYD RQRW
Target Information
A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, commonly found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein encoded by sequences from both BCR and ABL genes. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product remains unclear. The protein exhibits serine/threonine kinase activity and acts as a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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