Thermo Fisher Scientific COL11A2 Polyclonal Antibody
Rabbit에서 유래한 COL11A2 폴리클로날 항체로 인간 Collagen XI alpha2 내부 영역의 합성 펩타이드에 특이적입니다. IHC(P)에서 1:50–1:100으로 사용 가능하며, 비결합형 액상 형태로 제공됩니다. 연구용으로만 사용되며 -20°C에서 보관합니다.
- 카탈로그번호
- PA538889
- 판매단위
- pk
카탈로그
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide derived from the internal region of human Collagen XI alpha2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2555481 |
Target Information
This gene encodes one of the two alpha chains of type XI collagen, a minor fibrillar collagen. It is located on chromosome 6 very close to but separate from the gene for retinoid X receptor beta. Type XI collagen is a heterotrimer, but the third alpha chain is a post-translationally modified alpha 1 type II chain. Proteolytic processing of this type XI chain produces PARP, a proline/arginine-rich protein that serves as an amino terminal domain.
Mutations in this gene are associated with:
- Type III Stickler syndrome
- Otospondylomegaepiphyseal dysplasia (OSMED syndrome)
- Weissenbacher-Zweymuller syndrome
- Autosomal dominant non-syndromic sensorineural type 13 deafness (DFNA13)
- Autosomal recessive non-syndromic sensorineural type 53 deafness (DFNB53)
Alternative splicing results in multiple transcript variants. A related pseudogene is located nearby on chromosome 6.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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