Thermo Fisher Scientific CHD5 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:500-1:1,000

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human CHD5. Recombinant protein control fragment (Product #RP-103713). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:CHD5,uniProtId:Q8TDI0-1,ncbiNodeId:9606,antigenRange:1574-1659,antigenLength:1954,antigenImageFileName:PA5-63133_CHD5_Q8TDI0-1_Rabbit.svg,antigenImageFileNamePDP:PA5-63133_CHD5_Q8TDI0-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2639759

Product Specific Information

Immunogen sequence: GYMDEKDPGA QKPRQPLEVQ ALPAALDRVE SEDKHESPAS KERAREERPE ETEKAPPSPE QLPREEVLPE KEKILDKLEL SLIHSR

Highest antigen sequence identity to the following orthologs: Mouse - 67%, Rat - 67%.

Target Information

CHD5 (Chromodomain helicase DNA binding protein 5) is a member of the SNF2/RAD54 helicase family of chromatin remodeling and DNA-binding proteins (CDH proteins). Heavily expressed in both fetal and adult brain, CHD5 plays a role in nervous system development and acts as a tumor suppressor via the Arf/p53 pathway. CHD5, along with other chromo-domain proteins, forms remodeling complexes, such as NuRD, that promote normal neuroblast maturation and are thought to prevent overexpression of neuronal cells. Errors in these chromatin remodeling complexes can leave the cell in a perpetual state of growth, preventing differentiation and leading to tumor formation. Due to the importance of the CHD proteins in proper brain development, deletions in the gene encoding CHD5 are commonly found in neuroblastomas, suggesting that CHD5 deficiency may lead to malignant cell transformation and metastasis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.