Thermo Fisher Scientific NRG1 Polyclonal Antibody
NRG1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체로, IHC(P) 등 다양한 연구용에 적합합니다. 인간에 반응하며, 고순도 항원 친화 크로마토그래피로 정제되었습니다. 액상 형태, 1 mg/mL 농도, 장기 보관은 -20°C에서 권장됩니다.
- 카탈로그번호
- PA534023
- 판매단위
- pk
카탈로그
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 5–10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 15 amino acid peptide from N-Terminus of human NRG1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2551381 |
Product Specific Information
Percent identity with other species by BLAST analysis:
Human, Gorilla, Gibbon (100%), Monkey (93%), Marmoset (80%).
Target Information
Neuregulin 1 (NRG1) is a 44-kD glycoprotein interacting with the NEU/ERBB2 receptor tyrosine kinase to increase phosphorylation on tyrosine residues. Multiple isoforms are produced by alternative splicing, including heregulins (HRGs), glial growth factors (GGFs), and sensory and motor neuron-derived factor (SMDF).
These isoforms are tissue-specific and structurally distinct:
- HRG isoforms: Contain immunoglobulin (Ig) and epidermal growth factor-like (EGF-like) domains.
- GGF/GGF2 isoforms: Include kringle-like sequence plus Ig and EGF-like domains.
- SMDF isoform: Shares only the EGF-like domain.
All NRG1 isoforms interact with ERBB family tyrosine kinase receptors, inducing growth and differentiation of epithelial, neuronal, glial, and other cell types.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일명: PA5-34023_NRG1_Q02297-1_Rabbit.svg, PA5-34023_NRG1_Q02297-1_Rabbit_PDP.jpeg)
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