Thermo Fisher Scientific CHD8 Polyclonal Antibody

Applications

Immunohistochemistry (IHC)

• Tested Dilution: 1:100–1:500

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:100–1:500

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt
• Based on 100% sequence identity, predicted to react with Mouse, Bovine, Horse, Rabbit, Guinea pig, Pig, Panda, Orangutan, Monkey, Gorilla, Chimpanzee, and Naked mole rat

Target Information

DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Functions as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to promoter regions of several CTNNB1 responsive genes. Involved in enhancer blocking and epigenetic remodeling at chromatin boundary via interaction with CTCF. Also acts as a suppressor of STAT3 activity and as a transcription activator via interaction with ZNF143, participating in efficient U6 RNA polymerase III transcription.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.