Thermo Fisher Scientific AR Monoclonal Antibody (OTI2H2), TrueMAB
인간 AR 단백질(aa 420-659)에 특이적인 마우스 단일클론 항체로 Western blot에 적합합니다. TrueMAB 형식으로 고순도 친화 크로마토그래피 정제 제품입니다. PBS, BSA, 글리세롤 완충액에 보관되며 -20°C에서 안정적으로 저장 가능합니다.
- 판매단위
- pk
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Applications
- Western Blot (WB)
Tested Dilution: 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2H2 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 420–659 of human AR produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Target Information
The androgen receptor (AR) is a member of the steroid-hormone receptor superfamily of nuclear receptors. It is a ligand-activated transcription factor that binds testosterone (T) and dihydrotestosterone (DHT). Upon ligand binding, AR dissociates from accessory proteins, translocates into the nucleus, dimerizes, and stimulates transcription of androgen-responsive genes.
AR plays a key role in the development and function of male reproductive organs such as the prostate and epididymis, and also functions in nonreproductive tissues including muscle, hair follicles, and brain. It acts as a phosphoprotein regulating MAP kinase signaling. Dysregulation of AR signaling is associated with diseases such as prostate cancer, Kennedy’s disease, and male infertility. Mutations in AR can cause complete androgen insensitivity syndrome (CAIS).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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