Thermo Fisher Scientific ARHGEF7 Polyclonal Antibody, FITC
ARHGEF7 단백질을 인식하는 FITC 결합 폴리클로날 항체. Western blot, ELISA, IP 등에 사용 가능. Human, Mouse, Rat 반응성. Affinity chromatography로 정제된 고순도 제품. 연구용으로만 사용.
- 카탈로그번호
- ARHGEF7-FITC
- 판매단위
- pk
카탈로그
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within amino acid region 595–805 on human ARHGEF7 protein |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 30% glycerol, 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The serine/threonine kinase, p21 activated kinase (PAK), is a downstream effector of the small GTPases Cdc42 and Rac. PAK associates with Nck, the p85 and p110 subunits of PI3-kinase, and PIX (PAK-interacting exchange factor) in a focal complex. The binding of PIX is necessary for localization and activation of PAK in the Cdc42–Rac signaling pathway, occurring through the high affinity of the N-terminal SH3 domain of PIX for a conserved proline-rich PAK sequence. PIX exists as two isoforms, alpha and beta, both highly expressed in heart, muscle, and thymus tissues of human and rat. AlphaPIX is phosphorylated via PDGF and EphB2 receptor signaling pathways or through association with PI3-kinase. The alphaPIX isoform predominantly acts as a guanine nucleotide exchange factor (GEF) on Rac, which may mediate lamellipodia formation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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