Thermo Fisher Scientific FBXW7 Monoclonal Antibody (OTI4E7), TrueMAB
인간 FBXW7 단백질(아미노산 1-354)에 특이적인 Mouse IgG2b 단클론항체. Western blot에 최적화(1:2000 희석). 액상형, 1 mg/mL 농도, PBS/BSA/glycerol 저장. 암 연구 및 단백질 분해 경로 연구용.
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Applications
Tested Application
- Western Blot (WB)
Tested Dilution
- 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4E7 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1–354 of human FBXW7 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
F-Box and WD Repeat Domain Containing 7 (FBXW7) is a member of the F-box protein family characterized by the approximately 40 amino acid F-box motif. These proteins form part of the SCF (SKP1-cullin-F-box) ubiquitin ligase complexes, which mediate phosphorylation-dependent ubiquitination.
FBXW7, also known as FBX30, belongs to the Fbws class and contains seven tandem WD40 repeats. It binds directly to cyclin E and likely targets it for ubiquitin-mediated degradation.
Mutations in FBXW7 have been detected in ovarian and breast cancer cell lines, suggesting a role in cancer pathogenesis. Multiple transcript variants encoding different isoforms are known.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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