Thermo Fisher Scientific SLC39A3 Polyclonal Antibody
인간 SLC39A3 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC(P), ICC/IF에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS와 글리세롤 버퍼에 보존. 아연 수송체 ZIP3 연구에 적합한 연구용 항체.
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Thermo Fisher Scientific SLC39A3 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:500 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human SLC39A3. Recombinant protein control fragment (Product #RP-99128). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2647502 |
Product Specific Information
Immunogen sequence:
TFRKEKPSFI DLETFNAGSD VGSDSEYESP FMGGARGHAL YVEPHGHGPS LSVQGL
Highest antigen sequence identity to the following orthologs:
- Mouse: 68%
- Rat: 68%
Target Information
The zinc transporter ZIP3, also known as SLC39A3, is a member of a family of divalent ion transporters. Zinc is an essential ion for cells and plays significant roles in growth, development, and differentiation. Similar to knock-outs of ZIP1 and ZIP2, ZIP3- mice have no phenotypic differences compared to wild-type mice. Only when ZIP1, ZIP2, and ZIP3 genes are all eliminated and these mutant mice are fed a zinc-deficient diet do abnormalities such as reduced embryonic membrane-bound alkaline phosphatase activity and abnormal development occur, indicating that the ZIP1-3 proteins play an important, noncompensatory role when zinc is deficient.
Recent studies show that ZIP2 and ZIP3 are downregulated in human prostate adenocarcinomatous glands, suggesting their importance in zinc retention within cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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