Thermo Fisher Scientific MYH9 Polyclonal Antibody
MYH9 단백질을 인식하는 Rabbit Polyclonal Antibody로, Human, Mouse, Rat 시료에 반응합니다. ELISA에 적합하며, 비결합(Unconjugated) 상태로 제공됩니다. Protein A 정제, 1 mg/mL 농도, PBS/50% glycerol/1% BSA buffer에 보관됩니다.
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Applications
- ELISA (ELISA)
- Tested Dilution: 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide derived from human non-muscle Myosin IIA (amino acids 1801–1960) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with 50% glycerol, 1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The MYH9 gene, located on chromosome 22q12.3, encodes the heavy chain of non-muscle myosin IIA (NMHC IIA), a critical component of the actin cytoskeleton that plays essential roles in various cellular processes.
Structurally, the MYH9 gene spans over 106 kilobases and includes 41 exons translating into a protein of 1,960 amino acids. This protein forms a hexameric complex composed of two heavy chains, two regulatory light chains, and two essential light chains.
NMHC IIA interacts with actin filaments and is involved in cellular activities such as migration, adhesion, division, and maintenance of cell shape.
Mutations in MYH9 can cause autosomal dominant MYH9-related diseases (MYH9-RD), including May-Hegglin anomaly, Fechtner syndrome, and Epstein syndrome, characterized by macrothrombocytopenia and possible complications such as hearing loss, renal failure, and cataracts.
MYH9 also plays an essential role in hematopoiesis, maintaining the survival of hematopoietic stem and progenitor cells (HSPCs). Loss of MYH9 function can lead to severe blood cell deficiencies and bone marrow failure.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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