ELK Biotechnology PDGFR-β (phospho Tyr751) rabbit pAb
PDGFR-β (phospho Tyr751) rabbit pAb는 인산화된 PDGFR-β를 특이적으로 인식하는 폴리클로날 항체입니다. WB, IHC, IF, ELISA에 사용 가능하며, 세포막 및 세포내 위치 연구에 적합합니다. 고순도 IgG 형태로 -20°C에서 1년간 안정적으로 보관 가능합니다.
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PDGFR-β (phospho Tyr751) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | PDGFR-β (phospho Tyr751) rabbit pAb |
| Alternative Names | PDGFRB; PDGFR; PDGFR1; Platelet-derived growth factor receptor beta; PDGF-R-beta; PDGFR-beta; Beta platelet-derived growth factor receptor; Beta-type platelet-derived growth factor receptor; CD140 antigen-like family member B |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | IHC: 1/100–1/300 IF: 1/200–1/1000 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human PDGF Receptor beta around the phosphorylation site of Tyr751 (AA range: 718–767) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 135–180 kDa |
| Gene ID (Human) | 5159 |
| Human Swiss-Prot No. | P09619 |
| Species Reactivity | Human; Mouse; Rat |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein; Cytoplasmic vesicle; Lysosome lumen. After ligand binding, the autophosphorylated receptor is ubiquitinated and internalized, leading to its degradation. |
Background
This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family, which are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or heterodimer composed of both PDGFR alpha and beta polypeptides. This gene is located on chromosome 5 near the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor, all potentially implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12 that fuses this gene to the ETV6 leukemia gene results in chronic myeloproliferative disorder with eosinophilia.
[Source: RefSeq, Jul 2008]
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