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ELK Biotechnology PAKγ rabbit pAb
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PAKγ rabbit pAb는 인간 PAK2 유래 펩타이드로 제작된 폴리클로날 항체로, WB, IHC, IF, ELISA에 적합합니다. 세포골격 재구성과 세포사멸 과정 연구에 유용하며, 사람·마우스·랫에서 반응성을 보입니다. -20°C에서 1년 보관 가능합니다.
- 판매단위
- pk
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ELK Biotechnology ES6471-100UL PAKγ rabbit pAb, 100UL pk판매 단위 pk ·
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ELK Biotechnology ES6471-50UL PAKγ rabbit pAb, 50UL pk판매 단위 pk ·
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ELK Biotechnology · ELK Biotechnology PAKγ rabbit pAb
제품명
PAKγ rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | PAK2; Serine/threonine-protein kinase PAK 2; Gamma-PAK; PAK65; S6/H4 kinase; p21-activated kinase 2; PAK-2; p58 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 ELISA: 1/5000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human PAK2. AA range: 5-54 |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 60 kD |
| Gene ID (Human) | 5062 |
| Human Swiss-Prot No. | Q13177 |
| Species Reactivity | Human; Mouse; Rat |
세포 내 위치 (Cellular Localization)
- Serine/threonine-protein kinase PAK 2: Cytoplasm. MYO18A mediates the cellular distribution of the PAK2-ARHGEF7-GIT1 complex to the inner surface of the cell membrane.
- PAK-2p34: Nucleus; Cytoplasm, perinuclear region; Membrane (Lipid-anchor). Interaction with ARHGAP10 probably changes PAK-2p34 location to cytoplasmic perinuclear region. Myristoylation changes PAK-2p34 location to the membrane.
배경 (Background)
The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell. [provided by RefSeq, Jul 2008]
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