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ELK Biotechnology PAKγ (phospho Ser192) rabbit pAb
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PAKγ (phospho Ser192) rabbit polyclonal antibody로, 인산화된 Ser192 부위를 인식합니다. WB 및 ELISA에 적합하며, 인간, 마우스, 랫트 시료에 반응합니다. 세포골격 재조직 및 세포자멸사 관련 연구에 활용 가능합니다.
- 판매단위
- pk
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ELK Biotechnology ES6467-100UL PAKγ (phospho Ser192) rabbit pAb, 100UL pk판매 단위 pk ·
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ELK Biotechnology ES6467-50UL PAKγ (phospho Ser192) rabbit pAb, 50UL pk판매 단위 pk ·
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301,000원VAT 포함 331,100원
ELK Biotechnology · ELK Biotechnology PAKγ (phospho Ser192) rabbit pAb
제품명
PAKγ (phospho Ser192) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | PAK2; Serine/threonine-protein kinase PAK 2; Gamma-PAK; PAK65; S6/H4 kinase; p21-activated kinase 2; PAK-2; p58 |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/5000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human PAK2 around the phosphorylation site of Ser192. AA range: 158–207 |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 58 kD |
| Gene ID (Human) | 5062 |
| Human Swiss-Prot No. | Q13177 |
| Species Reactivity | Human; Mouse; Rat |
세포 내 위치
- [Serine/threonine-protein kinase PAK 2]: Cytoplasm.
MYO18A mediates the cellular distribution of the PAK2-ARHGEF7-GIT1 complex to the inner surface of the cell membrane. - [PAK-2p34]: Nucleus. Cytoplasm, perinuclear region. Membrane; Lipid-anchor.
Interaction with ARHGAP10 probably changes PAK-2p34 location to cytoplasmic perinuclear region.
Myristoylation changes PAK-2p34 location to the membrane.
Background
The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling.
The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities.
The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis and may play a role in regulating apoptotic events in the dying cell.
[provided by RefSeq, Jul 2008]
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