ELK Biotechnology PAKα (phospho Ser204) rabbit pAb
PAKα (phospho Ser204) rabbit pAb는 인산화된 PAK1 단백질을 인식하는 폴리클로날 항체로, WB, IHC, IF, ELISA에 적합합니다. 세포 이동 및 형태 조절 연구에 활용되며, 인간, 마우스, 랫트 시료에 반응합니다. -20°C에서 1년 보관 가능합니다.
- 카탈로그번호
- ES6458-xxxxx (2개 옵션)
- 판매단위
- pk
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제품명
PAKα (phospho Ser204) rabbit pAb
제품 개요
PAKα (phospho Ser204) rabbit pAb는 인간 PAK1 단백질의 Ser204 인산화 부위를 인식하도록 제작된 폴리클로날 항체입니다. 세포 골격 재구성, 세포 이동, 신호 전달 연구에 유용합니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | PAKα (phospho Ser204) rabbit pAb |
| Alternative Names | PAK1; Serine/threonine-protein kinase PAK 1; Alpha-PAK; p21-activated kinase 1; PAK-1; p65-PAK |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 ELISA: 1/5000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human PAK1 around the phosphorylation site of Ser204 (AA range: 170–219) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 65 kDa |
| Gene ID (Human) | 5058 |
| Human Swiss-Prot No. | Q13153 |
| Species Reactivity | Human; Mouse; Rat |
세포 내 위치 (Cellular Localization)
Cytoplasm; Cell junction (focal adhesion); Cell projection (lamellipodium, ruffle membrane, invadopodium); Cell membrane; Nucleus (nucleoplasm); Chromosome; Cytoskeleton (microtubule organizing center, centrosome).
Recruited to the cell membrane by interaction with CDC42 and RAC1. Localized to focal adhesions upon activation and colocalized with CIB1 within membrane ruffles during cell spreading. Upon DNA damage, translocates to the nucleoplasm when phosphorylated at Thr-212 and co-recruited with MORC2 on damaged chromatin (PubMed:23260667).
Background
This gene encodes a member of the serine/threonine p21-activated kinase (PAK) family. PAK proteins are key effectors linking Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for small GTP-binding proteins such as Cdc42 and Rac, regulating cell motility and morphology. Alternatively spliced transcript variants encoding different isoforms have been identified (RefSeq, Apr 2010).
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