ELK Biotechnology Trk A rabbit pAb
ELK Biotechnology의 Trk A rabbit pAb는 인간, 마우스, 랫트에서 반응하는 다클론 항체로, WB, IHC, IF, ELISA에 사용 가능합니다. 신경영양 인자 수용체 연구에 적합하며, 고순도 IgG 형태로 -20°C에서 1년간 안정 보관됩니다.
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Trk A rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Trk A rabbit pAb |
| Alternative Names | NTRK1; MTC; TRK; TRKA; High affinity nerve growth factor receptor; Neurotrophic tyrosine kinase receptor type 1; TRK1-transforming tyrosine kinase protein; Tropomyosin-related kinase A; Tyrosine kinase receptor; Tyrosine kinase receptor A |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | IHC: 1/100–1/300; ELISA: 1/5000 (other applications not yet tested) |
| Immunogen | Synthesized peptide derived from human Trk A (AA range: 666–715) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 140–180 kDa |
| Gene ID (Human) | 4914 |
| Human Swiss-Prot No. | P04629 |
| Species Reactivity | Human; Mouse; Rat |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein. Localized at early, late, and recycling endosomes. Rapidly internalized after NGF binding and transported via retrograde axonal transport. Colocalized with RAPGEF2 at late endosomes. |
Background
This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation, and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date. [RefSeq, Jul 2008]
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