ELK Biotechnology B23 (phospho Thr234) rabbit pAb
B23 (phospho Thr234) rabbit pAb는 인산화된 NPM1 단백질을 인식하는 폴리클로날 항체로, WB, IHC, IF, ELISA에 사용됩니다. 사람, 마우스, 랫트 시료에 반응하며 핵 및 세포질 단백질 연구에 적합합니다. -20°C에서 1년 보관 가능합니다.
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제품명
B23 (phospho Thr234) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | NPM1; NPM; Nucleophosmin; Nucleolar phosphoprotein B23; Nucleolar protein NO38; Numatrin |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human NPM around the phosphorylation site of Thr234 (AA range: 201-250) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 38 kD |
| GeneID (Human) | 4869 |
| Human Swiss-Prot No | P06748 |
| Species Reactivity | Human; Mouse; Rat |
세포 내 위치
Nucleus, nucleolus, nucleoplasm, cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Generally nucleolar, but translocated to the nucleoplasm in case of serum starvation or treatment with anticancer drugs.
Found in cytoplasm in patients with primary acute myelogenous leukemia (AML), but not in secondary AML.
Can shuttle between cytoplasm and nucleus.
Co-localizes with methylated RPS10 in the granular component (GC) region of the nucleolus, and with nucleolin and APEX1 in nucleoli.
Isoform 1 of NEK2 is required for localization to the centrosome during mitosis.
배경(Background)
This gene encodes a phosphoprotein that moves between the nucleus and the cytoplasm. The gene product is involved in processes including regulation of the ARF/p53 pathway.
Several fusion partners have been characterized, notably the anaplastic lymphoma kinase gene on chromosome 2.
Mutations in this gene are associated with acute myeloid leukemia.
More than a dozen pseudogenes of this gene have been identified.
Alternative splicing results in multiple transcript variants. [RefSeq, Nov 2009]
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